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Peer Reviewed Articles on Alkaline Water

Posted by admin on September 12, 2008
Acid/Alkaline, Anti-aging, Kidney Function, health benefits, osteoporosis / No Comments

 Research on the need for maintaing the body’s acid/alkaline balance is now beginning to surface in the West. In Japan there is a large body of scientific evidence from the last 20+ years as to the importance of body pH to good health and wellbeing, and the challenges our bodies face in keeping it in balance, and now in the USA independent researchers are making some significant discoveries.


Here is a selected list of some of the peer-reviewed articles.



1. Lonergan, E. Aging and the kidney: adjusting treatment to physiologic change, Geriatrics 43: 27-30, 32-33, 1998.

Changes in renal physiology and function with aging put the elderly patient at risk for adverse effect of drug therapies due to the incidence of common problems like metabolic acidosis.

2. Frassetto, L. and Sebastian, A. Age and systemic acid-base equilibrium: analysis of published data, Journal of Gerontology, Advanced Biological Science and Medical Science, 51: B91-99, 1996.

Authors examined peer-reviewed literature to determine whether systemic acid-base equilibrium changes with aging in normal adults humans. Using linear regression analysis, they found that with increasing age, there is a significant increase in the steady-state blood H+ indicating a progressively worsening low-level metabolic acidosis in what may reflect, in part, the normal decline of renal function with increasing age.

3. Alpern, R. and Sakhaee, K. The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity, American Journal of Kidney Disease 29: 291-302, 1997.

Chronic metabolic acidosis is a process whereby an excess acid load is placed on the body due to excess acid generation or diminished acid removal by normal homeostatic mechanisms. Excessive meat ingestion and aging are two clinical conditions often associated with chronic metabolic acidosis. The body’s homeostatic response to this pathology is very efficient. Therefore, the blood pH is frequently maintained within the "normal" range. However, these homeostatic responses engender pathologic consequences such as nephrolithiasis, bone demineralization, muscle protein breakdown and renal growth.

4. Bushinsky, D. Acid-base imbalance and the skeleton, European Journal of Nutrition 40: 238-244, 2001.

Humans generally consume a diet that generates metabolic acids leading to a reduction in the systemic bicarbonate and a fall of pH. Chronic metabolic acidosis alters bone cell function; there is an increase in osteoclastic bone resorption and a decrease in osteoblastic bone formation. As we age, we are less able to excrete metabolic acids due to the normal decline in renal function.

5. Frassetto, L.; Morris, R.; Sellmeyer, D.; Todd, K. and Sebastian, A. Diet, evolution and aging: the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet, European Journal of Nutrition 40:5 200-213, 2001.

Dietary changes over the last two centuries have resulted in a mismatch between genetically-determined nutritional requirements in humans. Excess sodium chloride, a deficiency of potassium and excess dietary acids that are not mediated by dietary bicarbonates lead to chronic low-grade metabolic acidosis that amplifies the age-related pathophysiological consequences in humans (such as loss of bone substance, increase in urinary calcium, disturbance in nitrogen metabolism, and low levels of growth hormone).

6. Frassetto, L.; Morris, R. and Sebastian, A. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline, American Journal of Physiology, 271: 1114-22, 1996.

Otherwise healthy adults manifest a low-grade, diet-dependent metabolic acidosis, the severity of which increases with age at constant rate described by an index of endogenous acid production, apparently due in part, to the normal age-related decline of renal function.

7. Alpern, R. Trade-offs in the adaptation to acidosis, Kidney International 47: 1205-1215, 1995.

Excessive dietary intake of protein with consequent increase in metabolic acid production result in compensatory mechanisms that lead to progression of kidney stones, bone disease, renal disease and a catabolic state.

8. Krapt, R. and Jehle, A. Renal function and renal disease in the elderly, Schweizerische Medizinische Wochenschrift, 130:11 398-408 2000.

Age-induced decline in renal functions explains, at least in part, clinically important age-related conditions including metabolic acidosis.

9. Adrogue, H. and Madias, N. Management of life-threatening acid-base disorders, New England Journal of Medicine 338: 26-34, 1998.

Acid-base homeostasis exerts a major influence on protein function, thereby critically affecting tissue and organ performance. Deviations in body acidity can have adverse consequences and when severe, can be life-threatening.

10. Maurer, M.; Riesen, W.; Muser, J.; Hulter, H. and Krapf, R. Neutralization of Western diet inhibits bone resportion independently of K intake and reduces cortisol secretion in humans, American Journal of Physiology and Renal Physiology 284: F32-40, 2003.

The acid load inherent in the Western diet results in mild chronic metabolic acidosis in association with a state of cortisol excess. An alkali balanced diet modulates bone resorption and the associated alterations in calcium and phosphate homeostasis.

11. May, R.; Kelly, R. and Mitch, W. Metabolic acidosis stimulates protein degradation in rat muscle by glucocorticoid-dependent mechanism, Journal of Clinical Investigations 77:614-621, 1986.

Chronic metabolic acidosis increases net muscle protein degradation in rat muscle tissue.

12. Meghji, S.; Morrison, M.; Henderson, B. and Arnett, T. pH dependence of bone resoption: mouse calvarial osteoclasts are activated by acidosis, American Journal of Physiological and Endocrinological Metabolism 280: E112-E119, 2001.

Osteoclast activity is modulated by small pH changes and is a key determinant of bone resorption in mouse calvarial cultures.

13. Nabata, T.; Morimoto, S. and Ogihara, T. Abnormalities in acid-base balance in the elderly, Nippon Rinsho 50: 2249-53, 1992.

Decline in the ability to adjust acid-base balance is a feature of aging. Regulation of pH ultimately depends on the kidneys and lungs, however, the ability of these organs is decreased with physiological aging. Renal insufficiency and/or chronic obstructive pulmonary disease and various drugs, such as diuretics, often affect the acid-base balance in the elderly.

14. Robergs, R. Exercise-induced metabolic acidosis: where do the protons come from?, Sport Science 5(2) sportsci.org/jour/0102/rar.thm, 2001.

The physiology of intense exercise that produces acidosis is far more complex than originally thought. In the transition to higher exercise intensity, proton release is even greater than lactate production which indicates acidosis is only partially related to production of "lactic acid."

15. Sebastian, A.; Harris, S.; Ottaway, J.; Todd, K. and Morris, R. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate, New England Journal of Medicine 330:25 1776-81 1994.

Endogenous acid produced by the metabolism of foods in ordinary diets abundant in proteins may contribute to the decrease in bone mass that occurs normally with aging. The oral administration of potassium bicarbonate at a dose sufficient to neutralize endogenous acid improves calcium and phosphorus balance, reduces bone resorption and creases the rate of bone formation.

16. Sebastian, A.; Frassetto, L.; Sellmeyer, D.; Merriam, R. and Morris, R. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors, American Journal of Clinical Nutrition 76:6 1308-1316, 2002.

Estimates of the net systemic load of acid in ancestral pre-agricultural diets as compared to contemporary diets reflect a mismatch between the nutrient compositions of the diet and genetically determined nutritional requirements. The result is that contemporary diets generate diet-induced metabolic acidosis in contemporary Homo Sapiens.

17. Wiederkebr, M. and Krapf, R. Metabolic and endocrine effects of metabolic acidosis in humans, Swiss Medical Weekly 2001:131, 127-132, 2001.

 

The statements enclosed herein have not been evaluated by the Food and Drug Administration. The products mentioned on this site are not intended to diagnose, treat, cure, or prevent any disease. Information and statements made are for education purposes and are not intended to replace the advice of your family doctor.

 

 


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Ray Kurzweil and Anti-aging

 

Futurist Ray Kurzweil

On Building Bridges Toward ImmortalityBy Jon VanZile

Ray Kurzweil is at war. A healthy 57-year-old who can rattle off streams of his own vital statistics, Kurzweil believes that humanity is standing on the brink of immortality—and all that is holding us back is our own evolutionary biology.

Thus Kurzweil fights a war against a protein-based machine—the human body—whose basic design is about to become obsolete. He figures he needs only to hold off disease and aging long enough, maybe 20 more years, to reap the rewards of a revolution in health technology that will rely on advanced gene therapy and robots the size of blood cells to grant life everlasting.

While his ideas might seem far-fetched, he points out that space flight and mass agriculture would have been inconceivable to earlier generations. Instead of believing in doubt, Kurzweil has chosen to believe in the future, and he backs up his vision with sound science and impressive credentials.

Ray Kurzweil

As a teenager, Kurzweil attracted attention for writing a computer program that composed piano music. After attending the Massachusetts Institute of Technology, he went on to a lucrative career as an inventor. His inventions, which include an optical character recognition program and a text-to-speech voice synthesizer, earned him the government’s National Medal of Technology and the $500,000 Lemelson-MIT Prize, the nation’s largest award for invention.

More recently, however, Kurzweil has turned his attention to two favorite subjects: health and technological innovation. His interest in both subjects has very personal roots. “In my mid-thirties, I was diagnosed with type II diabetes,” he recalls. “Because my father died early of heart disease, I also had a disposition for high cholesterol. I followed the conventional treatment for a while, but it really made things worse and caused me to gain weight.”

Gaining weight and unhappy, Kurzweil decided to approach the problem like an inventor, as “someone who could find a solution to the problem.” He immersed himself in the scientific literature and soon designed a health program, based on diet modification and nutritional supplementation, that reversed his diabetes without medical intervention. This program became the subject of a bestselling book, The Ten Percent Solution for a Healthy Life, published in 1994.

Since then, Kurzweil has taken his theories even further. With the rate of technological innovation increasing exponentially, he believes it is only a matter of years—decades at most—until futuristic technologies will entirely reverse-engineer the human machine. “We’re beginning to understand biology and health, disease and aging, as information processes,” he explains. “We’re learning very precisely the sequences of steps concerning genes, proteins, and enzymes—and the sharing of information from one biochemical step to the next—that underlie aging and disease.”

Terry Grossman, MD

The trick, Kurzweil says, is to live long enough for scientists to unlock the biological riddle of aging. To do that, he advises people to use every weapon at their disposal to defy aging. These weapons include the most sophisticated, up-to-the-minute health information available and extensive dietary supplementation to replace nutrients lost to the aging process.

Kurzweil himself takes 250 supplements every day, while closely tracking and monitoring about 50 different measures of his own health. At any given time, he knows his exact levels of cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), triglycerides, homocysteine, and C-reactive protein, as well as his blood concentrations of various antioxidants and nutrients. “I haven’t aged much in the last 15 years,” he says.

His program is presented in Fantastic Voyage: Live Long Enough to Live Forever, a new book he coauthored with Terry Grossman, MD. According to Kurzweil, “Radical life extension is close at hand.”

Bridges to the Future

To make their theories easier to understand, Kurzweil and Grossman have developed three “bridges,” each of which must be crossed before humanity reaches immortality.

The first bridge is classic life extension, based on the most advanced science available today. It draws on much of the same science reported each month in Life Extension magazine. In fact, Kurzweil is a regular reader of Life Extension and supports the Foundation’s products.

“Bridge One involves learning about how the body’s different systems work,” Kurzweil explains. “Insulin resistance . . . methylation . . . atherosclerosis . . . cancer. They say that aging and disease are 80% genes and 20% lifestyle. That’s only true if you follow the usual, watered-down, compromised approach. If you’re aggressive, you can overcome almost any genetic disposition.

“Atherosclerosis is the perfect example. Only 25 years ago, scientists had only a rudimentary understanding of heart disease. Today, however, we understand atherosclerosis as an inflammatory condition that may begin in childhood and can be treated and even reversed through healthy lifestyle decisions, including frequent exercise, dietary choices that reduce inflammation, and aggressive supplementation with nutrients that reduce cholesterol.

“A lot of people feel that they shouldn’t take a supplement or medication unless it’s a last resort. That’s not the case. Evolution is not on our side. We need to aggressively reprogram our biochemistry, and that’s what my program does.” Because every person’s biology is different, Kurzweil’s program is individualized, but based on concepts that will be familiar to readers of Life Extension. Following are some of the program’s key recommendations.

You are what you drink

The human body comprises various fluids, ranging in pH from very acidic (stomach acid, for example) to rather alkaline (pancreatic fluid), and many bodily fluids have very narrow parameters. For example, the fluid within our cells ranges in pH from 6.8 to 7.1, while blood pH exists in a very narrow, slightly alkaline band of between 7.35 and 7.45.

Any disruption to this careful pH balance is dangerous. Unfortunately, it is easy for the body’s fluids to become too acidic, because many metabolic processes produce acidic by-products. According to Kurzweil, good health depends on maintaining a slightly alkaline pH level, so he recommends avoiding acidic beverages such as soft drinks and drinking purified water that has been treated to adjust its pH level. This promotes powerful detoxification and health-promoting effects, says Kurzweil.

Reduce your glycemic load

This concept is receiving more attention as scientists continue to unravel the relationships between blood sugar, obesity, diabetes, and heart disease, conditions that have one thing in common: excess carbohydrate intake. Kurzweil recommends dramatically reducing carbohydrate intake, especially for those with type II diabetes or insulin resistance.

Not all carbohydrates are equal, however. Simple carbohydrates, such as refined sugar, cause a rapid elevation in blood sugar, thus provoking an insulin response as the body produces extra insulin to bring the blood sugar level down. Over time, the body’s system for controlling blood sugar breaks down and diabetes develops. Diabetes and heart disease are closely associated.To prevent this vicious cycle, Kurzweil recommends that people avoid simple carbohydrates, opting instead for foods with a lower glycemic load. The glycemic load is calculated by multiplying the number of grams of carbohydrates in a given food by its glycemic index (which measures how quickly the food is converted into glucose and released into the bloodstream). The glycemic load is an accurate measure of how much insulin your body will have to produce to neutralize the carbohydrates in a given food.

Carbohydrates with a low glycemic load include peanuts, carrots, lentils, and kidney beans. By contrast, carbohydrates with a high glycemic load include all candy and refined sugar, white rice, potatoes, pasta, and white bread.

Carbohydrates should account for no more than one third of total caloric intake, says Kurzweil. People with diabetes or insulin resistance should limit their carbohydrate intake even further.

Choose your fats wisely

It is well known that Americans eat too much fat, but only recently have many people begun to pay attention to the kinds of fat they eat.

In Kurzweil’s view, fat itself is an outdated form of energy storage in humans, one that made sense when calories were scarce, hunting was uncertain, and winters were long. In today’s era of abundance, however, fat storage is yet another example of biology sabotaging our well-being.

Kurzweil’s program admonishes people to stay away from unhealthy saturated and trans fats, but also recommends that we pay more attention to the kind of healthy, unsaturated fats we eat, particularly omega-3 and omega-6 fatty acids. Omega-6 fatty acids, found in plant-based oils, and omega-3 fatty acids, abundant in sources such as fish, walnuts, and flaxseed, are both unsaturated fats, though they act very differently in the body. Omega-6 fatty acids encourage inflammation, while omega-3 fatty acids are anti-inflammatory. Inflammation has been linked to a host of degenerative conditions, including heart disease, diabetes, Alzheimer’s disease, and arthritis.

The modern American diet, which typically is high in processed plant oils, encourages consumption of far too much pro-inflammatory omega-6 fatty acids. The Kurzweil program recommends high levels of omega-3 fatty acids, such as ALA (alpha-linolenic acid), EPA (eico-sapentaenoic acid), and DHA (docosahexaenoic acid). EPA and DHA especially have been shown to lower triglyceride levels dramatically.

At the same time, Kurzweil’s program recommends incorporating certain omega-6 fatty acids such as GLA (gamma-linolenic acid) in the diet to lower blood pressure, cholesterol, and heart attack and stroke risk. Another healthy omega-6 fatty acid is DGLA (dihomogamma-linolenic acid).

Kurzweil recommends that fat make up no more than 25% of daily caloric intake, and that virtually all of this should be in the form of healthy fats. Saturated fats should account for no more than 3% of total calories.

Visit http://www.lef.org/magazine/mag2005/sep2005_report_kurzweil_01.htm for the rest of this story.

 


The Real Water Club - Real Water

I love the idea of Real Water Concentrate from The Real Water Club. It comes in a 4 ounce dropper bottle that is convenient and extremely portable. It is wonderful to know that every time I have a drink I am giving my body exactly what it needs to reverse aging and ill health. You can order Real Water Concentrate from The Real Water Club. Membership to The Real Water Club is free and the Real Water Concentrate is only $39.95 for a month’s supply.

 

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